This round table explores cutting-edge technologies through a Southern lens, fostering dialogues between old and new, North and South, body and machine, inclusivity and accessibility, past and future. As AI advances, becoming stronger and more indistinguishable from human intelligence, it's crucial to consider the developing world's needs. This ensures everyone benefits from scientific and technological advancements, especially those that push the boundaries of our knowledge. Researchers from the TWAS-IAP-OWSD network will showcase thriving, cutting-edge research across the global South.