venerdì 23 Settembre 2022 / ore 15:00 - 16:15
— Regione Autonoma Friuli Venezia Giulia
Piazza Unità d'Italia, 1, Trieste, Italia
HUMAN PAPILLOMAVIRUSES: FROM INFECTIOUS ENTRY TO MALIGNANCY
Lingua: english
Keynote lecture by
Lawrence Banks, direttore generale ICGEB / general director ICGEB
Human Papillomaviruses (HPVs) are the causative agents of cervical cancer, which remains one of the most prevalent cancers in the world. The presentation will commence with an overview of HPV and the life cycle, highlighting key steps in the progression to the development of malignancy. My laboratory is interested in the processes whereby HPVs gain access to the basement membrane and are then trafficked through the infected cell resulting in the viral genome accessing the nucleus. This process involves recruitment of cellular proteins involved in the regulation of the endocytic sorting machinery. Studies will be presented highlighting how components of the viral capsid interact with this endocytic machinery and thereby facilitate escape from lysozomal degradation. The other topic of research focusses on the mode of action of the E6 and E7 oncoproteins. These are responsible for maintaining and driving tumour development. Our studies have centred on understanding how they disrupt cellular homeostasis and in particular how these processes are regulated by post translational modifications. Recent work highlighting a novel association between the E7 oncoprotein and components of endocytic transport will also be discussed.
A panel by ICGEB
The event will be held in English without translation